ny unfortunate cases the virus
spreads from the point of inoculation to the entire system and destroys
the wretched mortal by extensive ulcers of the face and hemorrhage or by
destruction of the lung tissue; in other cases, however, glanders may
develop, as in the dog, in local form only, not infecting the
constitution and terminating in recovery, while the specific ulcer by
proper treatment is turned into a simple one. In the feline species
glanders is more destructive than in the dog. The point of inoculation
ulcerates rapidly and the entire system becomes infected.

While a student the writer saw a lion in the service of Prof. Trasbot,
at Alfort, which had contracted the disease by eating glandered meat and
died with the lung riddled with nodules. A litter of kittens lapped the
blood from the lungs of a glandered horse on which an autopsy was being
made, and in four days almost their entire faces, including the nasal
bones, were eaten away by rapid ulceration. Nodules were found in the
lungs. A pack of wolves in the Philadelphia Zoological Garden died in 10
days after being fed with the meat of a glandered horse. The rabbit,
guinea pig, and mice are especially susceptible to the inoculation of
glanders, and these animals are convenient witnesses and proofs of the
existence of suspected cases of the glanders in other animals by the
results of successful inoculations.

The primary lesion in any form is a local point in which occurs a rapid
proliferation of the cell elements which make up the animal tissue with
formation of new connective tissue, with a crowding together of the
elements until their own pressure on one another cuts off the
circulation and nutrition, and death takes place in them in the form of
ulceration or gangrene. Following this primary lesion we have an
extension of infection by means of the spread of the bacilli into those
tissues immediately surrounding the first infected spot, which are most
suitable for the development of simple inflammatory phenomena or the
specific virus. The primary symptoms are the result of specific reaction
at the point of inoculation, but at a later time the virus is carried by
means of the blood vessels and lymphatic vessels to other parts of the
body and becomes lodged at different places and develops in them; again,
when the disease has existed in the latent form in the lungs of the
animal and the virus is wakened into action from any cause, we have it
carried to vario