a rise
of temperature. If uncomplicated, the infection runs a chronic course,
terminating in death in from two months to one and one-half years, or
even longer. The probability of the virus being spread by an
intermediate host, such as flies, mosquitoes, internal parasites, etc.,
is now receiving careful investigation.

From experiments already conducted it appears that this disease,
formerly supposed to be confined to Manitoba and Minnesota, is more or
less prevalent in Kansas, Nebraska, Colorado, Wyoming, Montana, North
Dakota, Virginia, Texas, and New York. It also occurs in Europe, having
been reported in Germany under the name of infectious anemia and in
France as infectious typho-anemia.

_Symptoms._--The disease is characterized by a progressive pernicious
anemia, remittent fever, polyuria, and gradual emaciation in spite of a
voracious appetite. It begins to manifest itself by a dull, listless
appearance and by general weakness, the animal tiring very easily. This
stage is followed closely by a staggering, swaying, uncertain gait, the
hind legs being mostly affected. There is also noted a weakness and
tenderness in the region of the loins, and at the same time the pulse,
though weak, stringy, and intermittent, increases in rapidity and may
run as high as 70. The temperature may rise to 103 deg. F. or higher,
remaining high for several days, and then dropping to rise again
irregularly. Toward the end of the disease the temperature occasionally
remains persistently high. The horse may improve for a time, but usually
this improvement is followed by a more severe attack than the first.
Venous regurgitation is sometimes noticed in the jugular before death.
The quantity of urine passed is enormous in some cases. Death finally
occurs from exhaustion or syncope.

The blood shows a slight decrease in the number of white blood cells,
while there is a gradual but marked diminution of red corpuscles, the
count running as low as 2,000,000 per cubic millimeter, the normal count
being 7,000,000. If the blood is drawn from such an animal, the
resulting red clot will be about one-fifth of the amount drawn.
Occasionally a slow dripping of blood-tinged serum from the nostrils is
observed as a result of this very thin blood oozing from the mucous
membranes. Petechiae, or small hemorrhagic points, are sometimes noticed
on the nictitating membrane and conjunctiva, while paleness of the
visible mucous membranes of the nose and mout