be lifted up from the
subcutaneous tissue. According to the nature and quantity of the
inoculated blood, these symptoms rapidly present themselves, and either
attain a maximum or are retarded until, varying from the fourth to the
thirteenth day, the tumor at the seat of inoculation will be found to
have lost a certain amount of its tension and tenderness. From this date
the swelling and edema gradually begin to grow less, until finally,
after a period of 10 to 14 days, the only sign left of the former
swelling is a slight thickening of the skin over the point of the
injection; but at the moment when the tension and tenderness of the
parts at the seat of inoculation become suddenly decreased a symptom of
the utmost clinical importance takes place, namely, at that moment the
parasite of surra enters the blood of the general circulation.

The temperature on the day of inoculation, and, in fact, for several
days afterwards, may remain normal in character, there being only a few
degrees difference between the morning and evening observations. In
other cases there may be a slight rise from the first evening, and a
gradual progressive rise until the swelling at the seat of inoculation
shows signs of reduction in size, when the temperature generally takes a
decided rise again, and may attain 104 deg. or 105.8 deg. F. This elevation will
last a varying period of from two to six days, and on the day following
its onset the ordinary symptoms of fever will be noticed, and in
addition there will be petechiae on the conjunctival membranes,
lacrimation, a slight mucous discharge from the nose, and in severe
cases some edema of the lower portion of the legs, and perhaps of the
sheath in horses. At the termination of the period of fever the
temperature will be found to have fallen to normal or nearly so; the
animal will present a brighter aspect, and there is every appearance of
its return to health; in a few days, however, the animal again appears
dull and half asleep; the temperature is elevated, a relapse takes
place, and a repetition of all the symptoms in the primary paroxysm,
including the reappearance of the parasite, is observed.

_Diagnosis._--A diagnosis may also be established by the
complement-fixation or agglutination tests with the sera from suspected
animals. This, however, can be carried out only in laboratories and
requires special facilities for its execution.

_Treatment._--No satisfactory treatment is known. Intrav