h is usually in evidence,
although they may have a yellow or mahogany tinge. Often a fluctuating,
pendulous swelling may appear on the lower lip, point of elbow, sheath,
legs, under the belly, or on some other pendent portion, especially late
in the disease, which is indicative of poor circulation, thinning of the
blood, and consequent loss of capillary action.

_Lesions._--After death the carcass is found to be very much emaciated
and anemic, the visible mucosa being very pale. This marked absence of
adipose tissue makes the skinning of the animal a difficult task.
Subcutaneous and intermuscular edema and hemorrhages are frequently
observed, although in many cases it is remarkable to see how few
macroscopic lesions may be present. The predominating and most constant
lesion is probably the petechiae, so often observed in the muscle or on
the serous membranes of the heart. The heart is generally enlarged and
may be the only organ to show evidence of disease. In other cases the
lungs may be studded with petechiae, with a serous exudate present in the
thoracic cavity. In addition to the petechiae already noted, the
pericardial sac generally contains an increased quantity of fluid. The
abdominal cavity may show peritonitis and a hemorrhagic condition of the
intestines, which probably result from overfeeding in consequence of the
ravenous appetite. The liver, although usually normal, sometimes
presents a few areas of degeneration. The spleen is at times found to be
enlarged and covered with petechiae. The kidneys may appear normal or
anemic and flaccid, but microscopically they usually show a chronic
parenchymatous degeneration. The lymph glands may be enlarged and
hemorrhagic.

_Diagnosis._--The diagnosis of the disease is not difficult, especially
in advanced stages. The insidious onset, remittent fever, progressive
emaciation and anemia, unimpaired or ravenous appetite, staggering gait
and polyuria are a train of symptoms which make the disease sufficiently
characteristic to differentiate it from other diseases affecting horses
in this country. The peculiar relapsing type of fever, the great
reduction in the number of red blood cells, and the absence of
eosinophila are sufficient to differentiate it from the anemias produced
by internal parasites, while it may be readily distinguished from surra
by the nonsusceptibility of cattle and by the great ease with which the
trypanosoma may be found in the latter affection.

_P