us parts of the body and developing in the most
susceptible regions or organs. The points of development are most
frequently determined by the activity of the circulation and the
effects of exterior irritants. For example, if a horse which has been so
slightly affected with the virus of glanders that no symptoms are
visible is exposed to cold, rain, or sleet, or by the rubbing of the
harness on the body and the irritation of mud on the legs, the disease
is liable to develop on the exterior in the form of farcy, while a
full-blooded horse which is employed at speed and has its lungs and
respiratory tract gorged with blood from the extreme use of these organs
will develop glanders as the local manifestation of the disease in the
respiratory tract.

The previous reference to the existence of glanders under the two forms
more commonly differentiated as glanders and as farcy, and our reference
to the various conditions in which it may exist as acute, chronic, and
latent, show that the disease may assume several different phases.
Without for a moment losing sight of the fact that all these varied
conditions are identical in their origin and in their essence, for
convenience of study we may divide glanders into three classes--chronic
farcy, chronic glanders, and acute glanders with or without farcy.

CHRONIC FARCY.

_Symptoms._--In farcy the symptoms commence by formation of little nodes
on the under surface of the skin, which rapidly infringe on the tissues
of the skin itself. These nodes, which are known as farcy "buds" and
farcy "buttons," are from the size of a bullet to the size of a walnut.
They are hot, sensitive to the touch, at first elastic and afterwards
become soft; the tissue is destroyed, and infringing on the substance of
the skin the disease produces an ulcer, which is known as a chancre.
This ulcer is irregular in shape, with ragged edges which overhang the
sore; it has a gray, dirty bottom and the discharge is sometimes thin
and sometimes purulent; in either case it is mixed with a viscous,
sticky, yellowish material like the white of an egg in consistency and
like olive oil in appearance. The discharge is almost diagnostic; it
resembles somewhat the discharge which we have in greasy heels and in
certain attacks of lymphangitis, but to the expert the specific
discharge is characteristic. The discharge accumulates on the hair
surrounding the ulcer and over its surface and dries, forming scabs
which become