es and cattle, characterized by alternating paroxysms and
intermissions and produced by a specific flagellate protozoan (_Trypanosoma
brucei_) in the blood. It is probably transmitted from animal to animal
solely by the bites of the tsetse fly. This insect is something like a
large house fly, and when it settles on a diseased animal, sucks the blood
and infects its proboscis, it is enabled on biting a second animal to
infect the latter by direct inoculation. This disease is found throughout a
large portion of central and southern Africa, along the low-lying and
swampy valleys. It has never occurred in the United States, nor is it known
to be present in the Philippines, but its relation to surra and the
possibility of its appearance in one of our island dependencies are the
reasons for including a few remarks at this time.

_Symptoms._--The chief symptoms in addition to the fever, which is usually
about 104 deg. to 105 deg. F., are the muscular wasting, progressive anemia, and
loss of power, together with the edema most marked about the head, legs,
abdomen, and genital organs. The urine is yellow and turbid, and
occasionally contains albumin and blood. There is paralysis of one or both
of the hind legs, difficult urination and defecation, labored breathing,
discharge from the eyes and nose, extreme thirst, and gradual extension of
paralysis to other parts of the body. The disease runs a chronic course,
lasting from three to six weeks in horses, and from one to six months in
cattle. Besides these animals, the mule, ass, buffalo, antelope, hyena,
camel, and dog contract the disease naturally, and sheep, goats, cats, and
small laboratory animals succumb to artificial inoculation.

_Lesions._--The spleen and lymphatic glands are enlarged. There are
sero-fibrinous exudates in the body cavities, the liver is enlarged and
engorged, heart flabby, and a catarrhal condition is present in the
respiratory passages. Pathological changes occur in the spinal cord. The
finding of the trypanosoma by microscopic examination of the blood will
be conclusive evidence for diagnosis.

_Treatment._--Treatment has not proved satisfactory. Quinin, arsenic,
methylene blue, and other drugs have been used, but without success.
Endeavors thus far made to produce immunity from this disease have likewise
been unavailing.

CATTLE FARCY.

This is a chronic disease of cattle occurring in France and the island of
Guadeloupe, West Indies. It is charac