r in the course of time, which may affect larger
portions of the body and lead to more or less dangerous ulcers. As a
rule the course of lupus, even of great extent, is not malignant and at
the most the alliance with _traumatic erysipelas_ and possibly the
appearance of _pulmonary consumption_ may succeed the affliction. In
cases of not too rare occurrence it has been observed that lupus has
developed into _cancer_, which has always resulted fatally.

The _treatment_ of lupus has principally been a _local_ one. Caustics
were applied to destroy lupous tubercles by direct action, and
furthermore recourse has been taken to the so-called mechanical
treatment, in which the ringworm was scraped out.

Our experiences relating to the mechanical treatment of lupus have
taught us the following.

Lupus can not be cured without destroying and removing the diseased and
affected tissue. That method which effects the most radical destruction,
protects most from relapses. Therefore the best method of treating lupus
is to cut out the diseased skin. But with the superficial spreading
peculiar to many cases of lupus this method can only be applied within
certain limits. Then again the secondary growths after an operation may
be of serious consequences.

Unfortunately it has not been possible before this to remove all
diseased portions, no matter what method was applied, because often tiny
lupous tubercles spring up which are almost invisible to the naked eye.
These tubercles will again be the starting point for another spreading
of lupus.

We will see that Koch's new method to cure has the advantage both to
make visible all tubercles, even those that have escaped our notice and
also to effect a cure in the shortest time even in old chronic cases
that have before this been considered incurable. It is especially
possible in this form of tuberculosis to follow the specific action of
the new remedy, as we will learn later on.

_Tuberculosis of the testicles_ is not so very rare, it is found in
about 2-1/2 per cent. of all men afflicted with pulmonary consumption.
It is more rarely met with in children than in men.

The conditions under which tuberculosis of the testicles and epididymis
developes are various inflammatory processes with existing disposition.
It is mostly gonorrhea or some other inflammation of the urethra, or
injured testicle. It occurs less frequently without any apparent cause.

According to the starting point of tub