of .002 and even .001 ccm., but that the quantity could be rapidly
increased from this low initial dose to that which could be easily
tolerated by the other patients. We generally proceeded in such a manner
that the patient at first received an injection of .001 ccm. and if a
rise in the temperature set in this dose was repeated once daily until
the reaction ceased. Only then the dose was increased to .002 ccm. and
applied till the reactions failed to appear. And so forth, always
increasing the dose only .001 or at the most .002 up to .01 ccm. and
higher. This mild procedure seemed to me imperative, especially with
such patient as were in a weak and feeble condition. Proceeding in the
manner just described we can easily attain the application of very light
doses with but slight attacks of fever and hardly perceptible to the
patient. Some of the stronger consumptives were treated with larger
doses from the beginning, partly with a forced increase in the dosing
when it seemed as though the favorable result was obtained in a
correspondingly shorter time. The action of the remedy on the
phthisicist generally seemed to be such that cough and expectoration
increased somewhat after the first injection, then gradually diminished
and in favorable cases disappeared entirely; the sputum lost its
purulent nature and became slimy. The number of bacilli as a rule did
not decrease until the sputum had attained a phlegmy appearance (only
such patients were selected for these experiments in whose
expectorations bacilli were contained). They entirely disappeared
temporarily, but were again met with from time to time until the
expectoration had completely stopped. At the same time the night-sweats
left off, and the patients improved in appearance and gained in weight.
All patients treated in the first stages of phthisis were freed from all
symptoms of disease in the course of 4-6 weeks so that they could be
considered as cured. Even patients with cavities not too large were
considerably improved and nearly healed. But in the case of such
consumptives, whose lungs contained many and large cavities no objective
improvement could be marked, although the expectoration diminished and
they appeared to feel much better. I am inclined to assume on the basis
of these experiences, that the _earliest stages of phthisis can with
certainty be cured by this remedy_.[3] This may also hold good in cases
that are not too far advanced.

In exceptional case