he human being from the experiments on
the animal without further confirmatory inquiry.

Man proved himself much more sensitive to the effects of the remedy than
the guinea pig. Up to two cubic centimeters and even more of the
undiluted fluid could be injected under the skin of a healthy guinea pig
without causing any particularly disparaging effect. In the case of a
fullgrown man on the other hand, 25 ccm. are sufficient to produce
intense results. In proportion to weight of body therefore 1/1500 of the
amount which has no noticeable effect on the guinea pig has a decidedly
strong effect on the man.

From an injection that I have made on my upper arm I have experienced
the symptoms which arise in man after an injection of 25 ccm., in short
they were the following: Three or four hours after the injection a
raking pain in the joints, languor, inclination to cough, oppressed
breathing, which rapidly increased; in the fifth hour I experienced
intense chills which lasted nearly an hour, at the same time nausea,
vomiting, increase of the temperature of the body to 39.6 deg. C. After
about 12 hours all these affectations ceased. The temperature sank and
reached the normal height the next day. Heaviness of the limbs and
languor lasted for a few more days, and for the same length of time the
place of injection remained red and painful.

The lower limit of effect of the curative for a healthy man is about
.01 ccm. (= 1 cubic centimeter diluted with a 100 parts) as numerous
trials have shown. The majority reacted on this dose with only light
pain in the joints and passing languor. With a few a slight rise in
temperature set in, to 38 deg. C. or a trifle higher.

Although there is a marked difference as regards the dose of the
curative (according to relative weight of body) between the animal
subject and man, an evident resemblance is shown in several other
qualities.

The most important of these qualities is _the specific action of this
remedy on tuberculous processes of whatever kind they may be_. I will
not relate the effects on the animal subject in this connection, as it
would lead too far, but will at once turn to the peculiar effects on
tuberculous human beings.

As we have seen, a healthy man reacts but little or not at all on
.01 ccm. The same is true of diseased persons, provided they are not
tuberculous. But the relations are entirely different with those
afflicted with tuberculosis; a marked general and also a l