diseased
tissues undergo mortification and are cast off as dead matter later on.
On other places it seems that a diminution or rather a kind of melting
of the tissue is caused, and to effect a complete disappearance a
repeated application of the remedy is necessary. As the required
histological investigation is wanting, it is impossible at the present
time to state with certainty how this result is brought about. Only
this much is known that it is not a destruction of the tubercle bacilli,
but that only the tissue containing the tubercular bacilli is affected
by the application of the remedy. In this, as the visible swelling and
reddening show, greater circulatory derangements are caused and with
these vital changes in the _assimilation_ which result in a more or less
rapid and thorough mortification of the tissue according to the manner
in which the remedy is allowed to act.

To make a short repetition, the remedy therefore does not destroy the
tubercle bacilli, but the tuberculous tissue; on dead tissue, for
instance, gangrenous cheesy matter, necrotic bones, etc., it does not
act; nor on tissue that has undergone mortification through the action
of the remedy itself. Living bacilli can still linger in such dead
masses of tissue, which are either cast out with the necrotic tissue, or
may possibly migrate under special conditions into the adjoining living
tissue.

This quality of the remedy must be particularly observed, if its full
specific action is to be obtained. Therefore we must first cause the
mortification of the tuberculous tissue, and then effect its removal as
soon as possible, for instance, by means of a surgical operation; but
where this is impossible and the excretion by the organisms themselves
is necessarily slow, we must attempt by continued application of the
remedy to protect the endangered living tissue from the immigration of
the parasites.

As the remedy acts only on living tissue and causes mortification of
tuberculous tissue, we can readily explain another exceedingly peculiar
property of the remedy, namely, that it can be given in rapidly
increased doses. This may apparently be explained as being based on
inurement. But noting that in about three weeks the dose may be
increased to 500 times the strength of the first one, it is
unquestionably something more than habit, as we know of nothing
analogous confirming such a rapid and farreaching adaptation to any
powerful drug.

This fact can r