toms in man resemble those observed in animals. There is fever,
sometimes vomiting, painful swallowing, heat and dryness of the mouth,
followed by an eruption of vesicles on the mucous membrane of the mouth,
and very rarely by similar ones on the fingers. The vesicles appear on the
lips, gums, cheek, and edge of the tongue, and are about the size of a pea.
The vesicles soon rupture, leaving a small erosion which is soon covered by
a thin crust under which the new formation of epithelium proceeds rapidly.
The skin eruption mostly appears on the hands, tips of the fingers, base of
the nails, and more seldom on the toes and other parts of the body. Besides
these local changes, during the course of the disease headache, pain in the
limbs, vertigo, abdominal cramps, vomiting, diarrhea, and weakness are
occasionally observed. The disease is seldom fatal, usually appearing in a
very mild form except in weakened children, in whom an accompanying
intestinal catarrh may lead to a fatal termination.

Veterinarians who have had considerable experience with the disease among
animals regard the human affection as by no means uncommon in countries
where foot-and-mouth disease prevails, but the disturbance of health is
usually too slight to come to the notice of the family physician.

But few outbreaks of the disease in man have occurred in the United States,
and therefore cases of its transmission to man in this country are rather
rare. Dr. James Law reports having observed the disease in man from
drinking infected milk during the epizootic of 1870 in the Eastern States,
but the outbreaks of 1880 and 1884 affected such a small number of animals
and were so quickly suppressed that no instance of its transmission to man
was recorded. A few cases have been reported by Brush accompanying the New
England outbreak of 1902. Similar reports have been likewise received
concerning the appearance of vesicular eruptions in the mouths of children
during the 1908 and 1914 outbreaks, and the history of these cases
incriminates the milk supply.

Experiments by Loeffler and Froesch, as well as recent experiments which
have been made in Denmark and Germany, indicate that the infection is
comparatively easy to destroy by heat or the usual antiseptics. Milk
pasteurized at a temperature of 60 deg. C. for 20 minutes is safe so far as
infection by foot-and-mouth disease is concerned.

SEPTICEMIA AND PYEMIA.

These two names are applied to diseased cond