ix
or eight days. Cases have been reported which became chronic and in which
death did not take place for a month or more. In some of the cases running
an acute course, symptoms of toxemia are present; there is a lack of
sensation of the skin, staggering gait, trembling, eyes fixed, neck at
times bent to one side, and the eyes showing a wild expression. At times
the animals appear as if in pain and look around at the flanks. In the
pectoral form they may stand with the forelegs wide apart in evident effort
to breathe more freely. Sometimes there is a champing of the jaws and a
very free flow of glairy saliva dropping from the mouth.

The prognosis is decidedly unfavorable and 80 to 90 per cent of the cases
result fatally.

_Lesions._--The characteristic lesions of hemorrhagic septicemia consist of
hemorrhagic areas in the subcutaneous, subserous, and muscular tissues, the
lymph glands, and the viscera; in fact, they are distributed more or less
widely throughout the body and vary in size from a mere speck to the
diameter of a half dollar or even larger. The superficial form presents
itself first as a doughy tumefaction of the skin about the region of the
throat, neck, dewlap, or legs, which pits on pressure. This tumefaction
consists essentially of a cerogelatinous exudate into the subcutaneous and
intermuscular tissues.

Bloody extravasations may take place in subcutaneous tissues in various
places, but they are usually seen about the lower portion of the neck. The
mucous membranes and submucous tissues of the mouth, tongue, pharynx, and
larynx become involved in the process and are greatly thickened, inflamed,
and infiltrated with serum. The mucous membrane becomes reddish purple, and
that of the nostrils may in addition show hemorrhagic spots on its surface.
The lymphatic glands in this region are also swollen and infiltrated with
bloody serum. The salivary glands are pale and dry. The pectoral type,
though at times existing alone, may coexist with the cutaneous form. The
inflammatory edema of the mouth extends to the mucous membrane of the
trachea and bronchi, producing an extensive thickening and a yellowish
infiltration. The lung shows interstitial thickening from the outpouring of
serum into its meshes. It may become pneumonic.

The diaphragm, heart sac, and heart walls show numerous hemorrhagic points
and larger bloody extravasations. Sometimes there is a serous pleurisy,
with more or less fibrinous exudate.