rposes prophylaxis alone should be relied
upon. The same sanitary precautions, such as isolation, disinfection, and
burial or burning of all dead carcasses, should be observed as for anthrax
and other highly infectious diseases. All the premises, barns, stalls,
litter, and stable utensils should be thoroughly disinfected. Separate the
apparently well animals from the sick by placing them in a separate lot.

Experiments by the Bureau of Animal Industry toward protective inoculation
of the exposed cattle on infected premises have been made and the results
have been so satisfactory that several commercial houses handling
biological products are manufacturing a vaccine for hemorrhagic septicemia
in accordance with the Government's experiments on this subject. The method
of preparing the vaccine is similar to that recommended by Lignieres. It
consists in growing the cultures of the organism of the disease at 42 to
43 deg. C. and preparing from them growing at this temperature two different
strengths of vaccine. The weaker vaccine, which is used for the first
injection, is grown for five days at this temperature, whereas the stronger
vaccine, for the second injection, is grown for only two days. These
vaccines are used with an interval of 10 days between the injections, the
dose being 1 cubic centimeter at each injection. The effect of this vaccine
in abating outbreaks already in progress has been highly satisfactory and
it is plain that the general introduction of preventive vaccination for
hemorrhagic septicemia must be of material benefit to the cattle raisers in
the infected districts.

VESICULAR ERUPTION OF THE GENITAL ORGANS.

This contagious disease is called coital exanthema or vesicular exanthema,
and is more or less prevalent on the Continent. It has also been observed
in the breeding districts of the United States. It is the subject of
legislation in Germany, and governmental statistics are published annually
concerning its distribution in the Empire. According to the reports from
Hungary 492 head of cattle were attacked during 1898, 587 in 1899, and 207
in 1900.

A similar or perhaps identical disease of horses has the same distribution
and is transmissible from horses to cattle and vice versa.

The disease may be defined as a highly contagious eruption situated upon
the external genital organs of both sexes and accompanied with little or no
general disturbance of health. The contagion, the nature of which re