Federal quarantine was issued October 19, 1914. A campaign to
check the spread of the disease and to stamp it out was immediately begun
by the United States Department of Agriculture in cooperation with the
State authorities. Quarantines against the movement of animals and certain
materials from the infected areas were declared, shipments were traced,
rumors investigated, and thorough inspections made in an effort to discover
all infected stock. As measures of eradication, diseased herds were
slaughtered and buried and the premises disinfected. The owners of live
stock and other property destroyed on account of the disease were
reimbursed to the extent of the appraised value, half of which is paid by
the Federal Government and half by the State. There were slaughtered
172,720 animals (76,575 cattle, 86,492 swine, 9,511 sheep, 133 goats, and 9
deer), in 3,482 herds. The total appraised value of these animals was more
than $5,800,000. The expense to the Federal Government of eradicating this
outbreak was about $4,540,000.

_Symptoms._--In three to six days, or even longer, after the exposure of
the animal to the infection the disease makes its appearance. It is usually
first indicated by the animal suffering from a chill, quickly followed by
an invasion of fever, which may cause the temperature to rise as high as
106 deg. F. These symptoms are not always present, or may be in so slight a
form as to escape notice. Following this in one or two days it will be
noticed that small vesicles or blisters about the size of hempseeds or peas
are making their appearance upon the mucous membranes of the mouth at the
border and upper surface of the tongue near the tip, the inside of the
cheeks, on the gums and the inner surface of the lips, or on the margin of
the dental pad. These little blisters contain a yellowish, watery fluid and
gradually become more extensive as the disease advances. Soon after the
eruptions have appeared in the mouth of the animal considerable swelling,
redness, and tenderness will be noticed about the feet, at the coronet, and
between the digits of each foot. A day or two later eruptions similar to
those within the mouth make their appearance upon these swollen regions of
the foot, and at this stage it is usual to find that like lesions have made
their appearance upon the perineum of the victim. In the case of milk cows
the udder, and more particularly the teats, show the same vesicular
eruption, but the latte