less, experiments have been made along these lines
with serum from recovered cases, but without any positive results.
Similar investigations have been conducted by others in Europe with
precisely the same results. With the tendency of the disease to produce
pathological lesions in the central nervous system, it seems scarcely
imaginable that a medicinal remedy will be found to heal these foci, and
even when recovery takes place considerable disturbance in the
functions, as blindness, partial paralysis, dumbness, etc., is liable to
remain. Indeed, when the disease once becomes established in an animal,
drugs seem to lose their physiological action. Therefore, with all the
previously mentioned facts before us, it is evident that the first
principle in the treatment of this disease is prevention, which consists
in the exercise of proper care in feeding only clean, well-cured forage
and grain and pure water. These measures when faithfully carried out
check the development of additional cases of the disease upon the
affected premises.

While medicinal treatment has proved unsatisfactory in most cases,
nevertheless the first indication is to clean out the digestive tract
thoroughly, and to accomplish this prompt measures must be used early in
the disease. Active and concentrated remedies should be given,
preferably subcutaneously or intravenously, owing to the great
difficulty in swallowing, even in the early stage. Arecolin in one-half
grain doses, subcutaneously, has given as much satisfaction as any other
drug. After purging the animal the treatment is mostly symptomatic.
Intestinal disinfectants, particularly calomel, salol, and salicylic
acid, have been recommended, and mild, antiseptic mouth washes are
advisable. Antipyretics are of doubtful value, as better results are
obtained, if the temperature is high, by copious cold-water injections.
An ice pack applied to the head is beneficial in case of marked psychic
disturbance. One-ounce doses of chloral hydrate per rectum should be
given if the patient is violent or if muscular spasms are severe. If the
temperature becomes subnormal, the animal should be warmly blanketed,
and if much weakness is shown this should be combated with stimulants,
such as strychnin, camphor, alcohol, atropin, or aromatic spirits of
ammonia. Early in the disease urotropin (hexamethylenamin) in doses of
25 grains, dissolved in water and given by the mouth every two hours,
appeared to have been res