the vesicle during
the progress of the disease, as well as the blood in the body after
death, contained the _Bacillus anthracis_, and when inoculated into
small animals produced rapid death, with all the symptoms and
post-mortem appearances characteristic of che disease as known to affect
them.

In internal anthrax there is no visible local manifestation of the
disease, and the spores or bacilli appear to gain access to the system
from the air charged with them, as in rooms where the contaminated wool
or hair is unpacked, or again during the process of sorting. The
symptoms usually observed are those of rapid physical prostration, with
a small pulse, somewhat lowered temperature (rarely fever), and
quickened breathing. Examination of the chest reveals inflammation of
the lungs and pleura. In some cases death takes place by collapse in
less than one day, while in others the fatal issue is postponed for
three or four days, and is preceded by symptoms of blood-poisoning,
including rigors, perspirations, extreme exhaustion, &c. In some cases
of internal anthrax the symptoms are more intestinal than pulmonary, and
consist in severe exhausting diarrhoea, with vomiting and rapid sinking.
Recovery from the internal variety, although not unknown, is more rare
than from the external, and its most striking phenomena are its sudden
onset in the midst of apparent health, the rapid development of physical
prostration, and its tendency to a fatal termination despite treatment.
The post-mortem appearances in internal anthrax are such as are usually
observed in septicaemia, but in addition evidence of extensive
inflammation of the lungs, pleura and bronchial glands has in most cases
been met with. The blood and other fluids and the diseased tissues are
found loaded with the _Bacillus anthracis_.

Treatment in this disease appears to be of but little avail, except as
regards the external form, where the malignant pustule may be excised or
dealt with early by strong caustics to destroy the affected textures.
For the relief of the general constitutional symptoms, quinine,
stimulants and strong nourishment appear to be the only available means.
An anti-anthrax serum has also been tried. As preventive measures in
woollen manufactories, the disinfection of suspicious material, or the
wetting of it before handling, is recommended as lessening the risk to
the workers. (J. Mac.)

ANTHROPOID APES, or MANLIKE APES, the name given to t