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pects the conditions were identical, yet in Altona only 328 persons died, against 8605 in Hamburg. In some streets one side lies in Hamburg, the other in Altona, and cholera stopped at the dividing line, the Hamburg side being full of cases and the Altona side untouched. In the following year, when Hamburg had the new filtered supply, it enjoyed equal immunity, save for a short period when, as we have said, raw Elbe water accidentally entered the mains. But water, though the most important condition, is not the only one affecting the incidence of cholera. The case of Grimsby furnished a striking lesson to the contrary. Here the disease obtained a decided hold, in spite of a pure water-supply, through the fouling of the soil by cesspits and defective drainage. At Havre also its prevalence was due to a similar cause. Further, it was conclusively proved at Grimsby that cholera can be spread by sewage-fed shell-fish. Several of the local outbreaks in England were traced to the ingestion of oysters obtained from the Grimsby beds. In short, it may be said that all insanitary conditions favour the prevalence of cholera in some degree. Preventive inoculation with an attenuated virus was introduced by W.M.W. Haffkine, and has been extensively used in India, with considerable appearance of success so far as the statistical evidence goes. Treatment. As already remarked, the latest manifestations of cholera show that it has lost none of its former virulence and fatality. The symptoms are now regarded as the effects of the toxic action of the poison formed by the micro-organisms upon the tissues and especially upon the nervous system. But this theory has not led to any effective treatment. Drugs in great variety were tried in the continental hospitals in 1892, but without any distinct success. The old controversy between the aperient and the astringent treatment reappeared. In Russia the former, which aims at evacuating the poison, was more generally adopted; in Germany the latter, which tries to conserve strength by stopping the flux, found more favour. Two methods of treatment were invariably found to give great relief, if not to prolong life and promote recovery--the hot bath and the injection of normal saline solution into the veins or the subcutaneous tissue. These two should always be tried in the cold and collapsed stages of cholera. See _Local Government Board Reports, 1892-93-94-95_; Clemow, _The Cholera Epi
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