lling out piteously and
vehemently and beseeching that his life be terminated by any means. In
desperation he often lay and writhed on the floor in agony. The intense
suffering lasted, as a rule, for about a half hour, but he was never
without pain of the neuralgic type. He was freer of pain in summer than
in winter. Exsection of the brachial plexus was performed, but gave
only temporary relief. The man died in his eighty-fourth year of senile
debility.

According to Osler the tubercula dolorosa or true fascicular neuroma is
not always made up of nerve-fibers, but, as shown by Hoggan, may be an
adenomatous growth of the sweat-glands.

Yaws may be defined as an endemic, specific, and contagious disease,
characterized by raspberry-like nodules with or without constitutional
disturbance. Its synonym, frambesia, is from the French, framboise, a
raspberry. Yaws is derived from a Carib word, the meaning of which is
doubtful. It is a disease confined chiefly to tropical climates, and is
found on the west coast of Africa for about ten degrees on each side of
the equator, and also on the east coast in the central regions, but
rarely in the north. It is also found in Madagascar, Mozambique,
Ceylon, Hindoostan, and nearly all the tropical islands of the world.
Crocker believes it probable that the button-scurvy of Ireland, now
extinct, but described by various writers of 1823 to 1857 as a
contagious disease which was prevalent in the south and in the interior
of the island, was closely allied to yaws, if not identical with it.
The first mention of the yaws disease is by Oviedo, in 1535, who met
with it in San Domingo. Although Sauvages at the end of the last
century was the first to give an accurate description of this disease,
many physicians had observed it before.

Frambesia or yaws was observed in Brazil as early as 1643, and in
America later by Lebat in 1722. In the last century Winterbottom and
Hume describe yaws in Africa, Hume calling it the African distemper. In
1769 in an essay on the "Natural History of Guiana," Bancroft mentions
yaws; and Thomson speaks of it in Jamaica. Hillary in 1759 describes
yaws in Barbadoes; and Bajou in Domingo and Cayenne in 1777, Dazille
having already observed it in San Domingo in 1742.

Crocker takes his account of yaws from Numa Rat of the Leeward Islands,
who divides the case into four stages: incubation, primary, secondary,
and tertiary. The incubation stage is taken from the date o