t present any perceptible alteration in texture or in
color. The patient was free from fever and made no complaint except a
slight headache. Rayer quotes another case in a man of sixty who had
been bitten three years previously by a dog that was not mad. He was
greatly frightened by the accident and every time he saw a dog he
trembled violently, and on one occasion he suffered a convulsive attack
for one and a half hours. The convulsions increased in number and
frequency, he lost his memory, and exhibited other signs of incipient
dementia. He was admitted to the hospital with two small wounds upon
the head, one above the left eyebrow and the other on the scalp,
occasioned by a fall on his entrance into the hospital. For several
days a great degree of insensibility of the skin of the whole body was
observed without any implication of the power of voluntary motion. He
was entirely cured in eighteen days.

Duhring reports a very rare form of disease of the skin, which may be
designated neuroma cutis dolorosum, or painful neuroma of the skin. The
patient was a boiler-maker of seventy who had no family history bearing
on the disease. Ten years previously a few cutaneous tubercles the size
and shape of a split-pea were noticed on the left shoulder, attended
with decided itching but not with pain. The latter symptom did not come
on until three years later. In the course of a year or two the lesions
increased in number, so that in four years the shoulder and arm were
thickly studded with them. During the next five years no particular
changes occurred either in lesions or in the degree of pain. The region
affected simply looked like a solid sheet of variously-sized,
closely-packed, confluent tubercles, hard and dense. The tubercles were
at all times painful to the touch, and even the contact of air was
sufficient to cause great suffering. During the paroxysms, which
occurred usually at several short intervals every day, the skin changed
color frequently and rapidly, passing through various reddish and
violet tints, at times becoming purplish.

As a paroxysm came on the man was in the habit of gently pressing and
holding the arm closely to his body. At one time he endured the attack
in a standing posture, walking the floor, but usually he seated himself
very near a hot stove, in a doubled-up, cramped position, utterly
unmindful of all surroundings, until the worst pain had ceased.
Frequently he was unable to control himself, ca