highly and
widely recommended in general paralysis, but there remains grave doubt as
to its utility in this disease.

_Toxicology._--The symptoms of Calabar bean poisoning have all been stated
above. The obvious antidote is atropine, which may often succeed; and the
other measures are those usually employed to stimulate the circulation and
respiration. Unfortunately the antagonism between physostigmine and
atropine is not perfect, and Sir Thomas Fraser has shown that in such cases
there comes a time when, if the action of the two drugs be summated, death
results sooner than from either alone. Thus atropine will save life after
three and a half times the fatal dose of physostigmine has been taken, but
will hasten the end if four or more times the fatal dose has been ingested.
Thus it would be advisable to use the physiological antidote only when the
dose of the poison--assuming estimation to be possible--was known to be
comparatively small.

CALABASH (from the Span. _calabaza_, a gourd or pumpkin, possibly derived
from the Pers. _kharlunza_, a melon), the shell of a gourd or pumpkin made
into a vessel for holding liquids; also a vessel of similar shape made of
other materials. It is the name of a tree (_Crescentia Cujete_) of tropical
America, whose gourd-like fruit is so hard that vessels made of it can be
used over a fire many times before being burned.

CALABASH TREE, a native of the West Indies and South America, known
botanically as _Crescentia Cujete_ (natural order, Bignoniaceae). The fruit
resembles a gourd, and has a woody rind, which after removal of the pulp
forms a calabash.

CALABOZO, or CALABOSO, an inland town of Venezuela, once capital of the
province of Caracas in the colonial period, and now capital of the state of
Guarico. Pop. (1891) 5618. Calabozo is situated in the midst of an
extensive _llano_ on the left bank of the Guarico river, 325 ft. above
sea-level and 123 m. S.S.W. of Caracas. The plain lies slightly above the
level of intersecting rivers and is frequently flooded in the rainy season;
in summer the heat is most oppressive, the average temperature being 88 deg.F.
The town is regularly laid out with streets crossing at right angles, and
possesses several fine old churches, a college and public school. It is
also a bishop's see, and a place of considerable commercial importance
because of its situation in the midst of a rich cattle-raising country. It
is said to have been an Indian town or