n large Quantities. In such Cases, after the Use of
Emetics and Purges, and the Ague was brought to have regular
Paroxysms, with free Intermissions, the Bark, given as just now
mentioned, removed the Ague and icteric Symptoms, without the least
bad Consequences.

Many Practitioners of great Repute have been prejudiced against the
Bark; and tell us, that the free Use of this Medicine often lays the
Foundation of Obstructions in the abdominal Viscera, especially when
it has been given where there was an icteritious Colour in the Eyes
and Countenance; and that, in such Cases, we ought not to give the
Bark till these Icteric Symptoms are gone. At first, I was very
cautious of giving it under such Circumstances; till meeting with some
Cases where the Paroxysms were severe, and became more frequent, while
the Patient was so low, as to be in Danger of sinking under the
Disorder, I gave the Bark freely, as the only Remedy capable of
preserving Life; which not only stopt the Ague, but carried off the
icteritious Symptoms[84], and restored the Patients to perfect Health.

[84] This agrees with what Mr. _Cleghorn_ remarks of Tertian
Fevers in his _Observations on the epidemic Diseases of the
Island of Minorca_, who says, "where there is an icteritious
Colour of the Eyes, we are likewise told, that the Cortex
should not be administered; though, in my Opinion, it is for
the most part dangerous to delay it, after the first
Appearance of that Symptom." Chap. iii. 2d edit. p. 205.

After this I gave it freely, in the Manner above mentioned, to some
Hundreds, with great Success; and I never saw any Mischief follow from
using it: Indeed sometimes, where it was given rather too soon, it did
not sit easy on the Stomach; and made the Patients hot and restless;
but, by laying it aside, these Effects immediately ceased; and
generally, after a little Time, the Paroxysms became milder and more
distinct, when the Bark was again administered, agreed with the
Stomach, and put an End to the Disorder; and I am now convinced, from
Experience, that the Cases in which the Bark has done Mischief, or
given Rise to Obstructions of the abdomenal Viscera, are but very
rare; and that these Mischiefs mostly arise from the Obstinacy of the
Disorder, and not from the Use of this Drug; for I have oftener
observed these Obstructions where little or no Bark had been used,
than where it was given freely[85]. What probably has given Ri