above four Pounds.

[86] I have seen the dead Bodies of four People opened, who
had those Swellings of the left Side, commonly called the
_Ague Cake_, which had come after Agues; and in all the
Swelling was owing to an Enlargement of the Spleen.

Some, whose Constitutions were worn out by these obstinate Agues, fell
into Consumptions and other pulmonic Disorders in the Winter, of which
they died. One Man died in the cold Fit[87].

[87] The cold Fit is the most dangerous Time of the Paroxysm,
and the greatest Part of those who die of Agues die at this
Time; one or two Instances of which I saw in the Military
Hospital at _Edinburgh_ in the Year 1746.--_Van Swieten_ says
he has seen the trembling and shaking so great in the Time of
the cold Fit of Quartans, that the Teeth have dropt out of
the Head. _Comment. in sect._ 749. _Aphorism. Boerhaav._ vol.
II. p. 511.

Where-ever the Ague continued long, and the Bark had no Effect, we
were obliged to lay it aside, and to try other Remedies adapted to the
present Circumstances of the Patient.

The mild Methods succeeded best; giving the saline Draughts and gentle
cooling Medicines to such as were strong and plethoric, and had the
aguish Paroxysms violent; and the gentle Aromatics and Bitters, or
Chalybeats, to those of a weakly Habit, or whose Fibres had been much
relaxed, and their Constitutions greatly injured by this or any other
preceding Disorder.

During these Courses, we gave at Times gentle Emetics; and if the
Patient complained of Gripes and Purging, which they frequently did,
in the Course of this Disorder, we gave a Dose of Rhubarb, or of some
other mild Purge; and after it other Medicines proper for this
Complaint.

By these Methods frequently the aguish Paroxysms became gradually
milder, and at last vanished. At other Times, after they had continued
for five or six Weeks, we again gave the Bark, and found it to have
the proper Effect. With others they continued thro' the Winter, and
went off of themselves in the Spring. With others they still
continued; and as no Medicines nor Time seemed to have any Effect in
that Country, we recommended their being sent over to _England_ for
Change of Air, as the only Means likely to remove the Disorder.

Two Agues which had resisted the Use of the Bark were cured by Powder
of Camomile-Flowers, Salt of Wormwood, and diaphoretic Antimony; and
one by the Use of the aluminous