ethods already
mentioned; though they often continued longer, required a greater
Quantity of the Bark to stop them, and a longer Continuance of its Use
to make a Cure, than at other Places, which were more dry, and higher
situated.

The most obstinate of the recent Cases were the irregular
Intermittents, which had regular Paroxysms, but where the Pulse was
not settled in the Intervals; which we were obliged to treat as
Remitting Fevers till the Paroxysms became quite distinct, and the
Patient was cool and free from any Fever in the Intervals; after which
they commonly yielded to the Bark.

But many of those Agues which had continued for some Time, especially
with those Invalids who came from _Embden_, or who had brought on
frequent Relapses by their own Irregularities, were very obstinate.
With many the Bark had no Effect; and its Use persisted in seeming
rather to exasperate the Paroxysms, and to do Hurt. Nor had almost any
Remedy we tried a better Effect. We gave the following Medicines to
divers Patients; the saline Draughts and cooling Medicines; Infusions
of Camomile Flowers and of other Bitters; Dr. _Morton_'s Powders of
Camomile Flowers, Salt of Wormwood, and diaphoretic Antimony; Dr.
_Mead_'s Powders of Camomile Flowers, Salt of Wormwood, Myrrh, and
Alum; Alum and Nutmeg; large Doses of _sal ammoniac_; large Quantities
of Spirits of Hartshorn; the antimonial Drops and Powders; to some we
gave Emetics, both in the Intervals and immediately before the Fits.
In some we tried to promote Sweats before the Approach of the Fits, by
making them drink freely of warm Liquors while they kept in Bed, and
took diaphoretic Medicines; and to others we applied Blisters.--But
all did not put a Stop to some of those Agues.

With some the Disorder continued till it broke down the Crasis of the
Blood, and brought on a general Relaxation of the Fibres; and the
Patients became cachectic, and fell into Dropsies, or were seized with
Diarrhoeas, of which they died. Some had Obstructions formed in the
Liver or Spleen, or other _viscera_, and fell into the Jaundice and
Dropsies, which carried them off.--In the Bodies, of several whom we
opened, we found Indurations of the Liver and Spleen--in two of them
Suppurations of the Liver--and in one, who had had the Ague at
_Embden_, and had long complained of one of those Swellings towards
the left Side of the _abdomen_, called the _Ague Cake_[86], the Spleen
was so much enlarged as to weigh