se to
the Belief of the Bark's doing so much Mischief, is, that in
_Holland_, and other low fenny Countries, where Agues are endemic,
they are oftentimes extremely obstinate, and yield hardly to any
Remedies; and if they are stopt by the Bark, they often return soon
after, and by their long Continuance give Rise to Obstructions of the
abdomenal _viscera_, which have been attributed to the Use of this
Specific.

[85] Dr. _Pringle_ takes Notice, that these Obstructions
happened as often without as with the Bark; and therefore
seemed to depend on the long Continuance and Obstinacy of the
Intermittent. _Observ._ part iii. chap. iv. sect. 2. p. 179.
3d Edit.

In some few Cases a Purging accompanied these icteric Symptoms, which
we treated much in the same Manner as when the Ague was complicated
with the Flux; we gave Emetics and Purgatives; and the mindereri
Draughts with Mithridate, throughout the Day, and Opiates at Night, if
the Purging was violent; if it continued, accompanied with regular
aguish Fits, the Bark, with Astringents, generally removed both.

In the latter Part of the Year 1761, and during Spring 1762, we had
at _Bremen_ many Patients in Agues of all Sorts; as Quotidians,
Tertians, Quartans, and irregular Agues of a very obstinate Nature.
The Town of _Bremen_ is large and well built, situated in a low sandy
Plain, with the _Weser_ dividing the old from the new Town; generally
a considerable Part of the Environs is covered with Water in the
Winter, and frequently the _Weser_ breaks down some of the Dikes, and
overflows all the Country round; and every Time the River overflows
its Banks, the Cellars of all the new Town, and of that Part of the
old Town next the River, are filled with Water. All the Year round, on
digging two or three Feet deep into the Ground, you come at Water.

Agues are endemic in this Place, and great Numbers of the lower Class
of People are afflicted with them at all Times of the Year, especially
in Spring and Autumn.

Some of the Sick sent down from the Army were bad of Agues; but the
greatest Number we had in Hospitals was composed of such as took it
in Town; either from doing Duty on the Ramparts, or from lying in bad
Quarters, or getting drunk and exposing themselves to Wet and Cold;
and many Men of the invalid Companies who had come from _Embden_
brought with them old inveterate tertian and quartan Agues.

Most of the recent Cases were easily cured by the M