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mong the silkworms; and I may mention a few facts which will give you some conception of the gravity of the injury which it has inflicted on France alone. The production of silk has been for centuries an important branch of industry in Southern France, and in the year 1853 it had attained such a magnitude that the annual produce of the French sericulture was estimated to amount to a tenth of that of the whole world, and represented a money- value of 117,000,000 francs, or nearly five millions sterling. What may be the sum which would represent the money-value of all the industries connected with the working up of the raw silk thus produced, is more than I can pretend to estimate. Suffice it to say, that the city of Lyons is built upon French silk as much as Manchester was upon American cotton before the civil war. Silkworms are liable to many diseases; and, even before 1853, a peculiar epizootic, frequently accompanied by the appearance of dark spots upon the skin (whence the name of "Pebrine" which it has received), had been noted for its mortality. But in the years following 1853 this malady broke out with such extreme violence, that, in 1858, the silk-crop was reduced to a third of the amount which it had reached in 1853; and, up till within the last year or two, it has never attained half the yield of 1853. This means not only that the great number of people engaged in silk growing are some thirty millions sterling poorer than they might have been; it means not only that high prices have had to be paid for imported silkworm eggs, and that, after investing his money in them, in paying for mulberry-leaves and for attendance, the cultivator has constantly seen his silkworms perish and himself plunged in ruin; but it means that the looms of Lyons have lacked employment, and that, for years, enforced idleness and misery have been the portion of a vast population which, in former days, was industrious and well-to-do. In 1858 the gravity of the situation caused the French Academy of Sciences to appoint Commissioners, of whom a distinguished naturalist, M. de Quatrefages, was one, to inquire into the nature of this disease, and, if possible, to devise some means of staying the plague. In reading the Report[11] made by M. de Quatrefages in 1859, it is exceedingly interesting to observe that his elaborate study of the Pebrine forced the conviction upon his mind that, in its mode of occurrence and propagation, the disease
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