ppeared in the course of nine
days but reappeared after the administration of the drug was resumed.
Lewin says that in this case the severity of the eruption was in
accordance with the size of the dose, and during its existence there
was bleeding at the gums; he adds that Gouchet also noticed an eruption
of this kind in a lady who after taking quinin expectorated blood. The
petechiae were profusely spread over the entire body, and they
disappeared after the suspension of the drug. Dauboeuf, Garraway,
Hemming, Skinner, and Cobner mention roseola and scarlatiniform
erythema after minute doses of quinin. In nearly all these cases the
accompanying symptoms were different. Heusinger speaks of a lady who,
after taking 1/2 grain of quinin, experienced headache, nausea, intense
burning, and edema, together with nodular erythema on the eyelids,
cheeks, and portion of the forehead. At another time 1 1/2 grains of
the drug gave rise to herpetic vesicles on the cheeks, followed by
branny desquamation on elimination of the drug. In other patients
intense itching is experienced after the ingestion of quinin. Peters
cites an instance of a woman of sixty-five who, after taking one grain
of quinin, invariably exhibited after an hour a temperature of from 104
degrees to 105 degrees F., accelerated pulse, rigors, slight delirium,
thirst, and all the appearances of ill-defined fever, which would pass
off in from twelve to twenty-four hours. Peters witnessed this
idiosyncrasy several times and believed it to be permanent. The most
unpleasant of the untoward symptoms of quinin exhibition are the
disturbances of the organs of special sense. Photophobia, and even
transient amblyopia, have been observed to follow small doses. In the
examination of cases of the untoward effects of quinin upon the eye,
Knapp of New York found the power of sight diminished in various
degrees, and rarely amaurosis and immobility of the pupils. According
to Lewin, the perceptions of color and light are always diminished, and
although the disorder may last for some time the prognosis is
favorable. The varieties of the disturbances of the functions of the
ear range from tinnitus aurium to congestion causing complete deafness.
The gastro-intestinal and genito-urinary tracts are especially disposed
to untoward action by quinin. There is a case recorded in which, after
the slightest dose of quinin, tingling and burning at the meatus
urinarius were experienced. According