s however of
moderate degree and does not exceed 7-10%. Out of 40 decided cases
Reinbach found the eosinophils increased only in four, in a case of
sarcoma of the forearm he found 7.8%; of the thigh 8.4%; malignant
tumour of the abdomen 11.6%. Besides these he describes a case of
lymphosarcoma of the neck with metastases in the bone-marrow, in which
an unexampled increase of the white blood corpuscles, and especially of
the eosinophil cells was found. The absolute number of the latter
amounted on one day to some 60,000! This is an increase of 300 fold the
normal, which apart from leukaemia has doubtless never before been
found.

7. =Compensatory eosinophilia= (after exclusion of the spleen). We have
entered in detail into this form in the chapter on splenic function; and
have there already mentioned that the increase of the eosinophils found
in chronic splenic tumours by Rieder, Weiss and others, must also be
referred to the exclusion of the splenic function.

8. =Medicinal eosinophilia.= Under this group occurs only a single
observation of v. Noorden's, who observed the appearance of an
eosinophilia up to 9% in two chlorotic girls after internal
administration of camphor. In other patients this occurrence did not
repeat itself. But probably researches specially directed to this
province of pharmacology would bring to our knowledge many interesting
facts.

On the origin of ~polynuclear eosinophil leucocytosis~ authors have put
forward various theories, which we will here critically discuss in
succession.

An experiment frequently quoted as explanatory is that of Mueller and
Rieder's; these authors do not derive the eosinophil cells of the blood
from the bone-marrow, but assume, as very probable, that the finely
granular cells grow into eosinophils within the blood-stream. This
developmental process seems very improbable for many reasons. Since the
polynuclear cells circulating in the blood are all under the same
conditions of nutrition, it is _a priori_ inconceivable why only a
relatively small portion of them should undergo the transformation in
question. And it is quite inexplicable why in infectious leucocytosis,
where the number of the polynuclears is increased so enormously, their
ripening to the eosinophils should remain completely interrupted.

But the fact, that a transition from neutrophil to oxyphil cells has
never really been observed in the blood, is decisive evidence against
the hypothesis of Mueller