h so, that in a case that was clinically obscure, he
made, from the marked eosinophilia, the diagnosis of trichinosis which
was later fully confirmed.
5. =Post-febrile form of eosinophilia= (after the termination of various
infectious diseases). In the section on polynuclear neutrophil
leucocytosis we have already mentioned that at the height of most of the
acute infectious diseases, with the single exception of scarlet fever,
the eosinophils undergo a relative decrease and may even entirely
disappear. In the post-febrile period, however, abnormally high values
for the eosinophil cells are often found, or even a well-marked
eosinophil leucocytosis, which generally attains but moderate degree.
Tuerk for example in pneumonia found a post-critical eosinophilia of
5.67% (430 absolute), after acute articular rheumatism 9.37% (970
absolute); Zappert in malaria, one day after the last attack 20.34%
(1486 per mm.^{3}).
The eosinophilia observed as the result of tuberculin injections, we
include, in agreement with Zappert, in the group of post-febrile
leucocytosis. For it appears only after considerable rises of
temperature. During the real reaction period the number of eosinophil
cells sinks, and only goes up again after the termination of the fever.
The rise may be very considerable. In one case of Zappert's the number
of the oxyphils increased to 26.9%; in another of his cases the highest
absolute figure formed after tuberculin injections was 3220 per mm.^{3}
In a case of Grawitz' the eosinophilia was quite extraordinary. The most
marked changes in the blood occurred some three weeks after cessation of
the tuberculin injections, of which eight altogether (from 5 mg. to 38
mg.) were given. Investigation shewed 4,000,000 red blood corpuscles per
mm.^{3}, 45,000 white. Amongst the latter there were ten eosinophils to
one non-eosinophil. The total number of eosinophil cells amounted to
some 41,000 per mm.^{3}, whilst the other cells as a whole made up some
4000. Inasmuch as the latter contained polynuclears, lymphocytes and
other forms, it follows that in this case the polynuclear neutrophils
must have been very much decreased, not only relatively but also
absolutely; so that this case represents precisely the contrary
condition to ordinary leucocytosis and the infectious form in
particular.
6. =In malignant tumours.= In the cachexia from tumours an increase of the
eosinophil cells has been observed by various authors. It i
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