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when Haller's theory was found to be entirely correct. It was in pursuit of experiments to establish his theory of irritability that Haller made his chief discoveries in embryology and development. He proved that in the process of incubation of the egg the first trace of the heart of the chick shows itself in the thirty-eighth hour, and that the first trace of red blood showed in the forty-first hour. By his investigations upon the lower animals he attempted to confirm the theory that since the creation of genus every individual is derived from a preceding individual--the existing theory of preformation, in which he believed, and which taught that "every individual is fully and completely preformed in the germ, simply growing from microscopic to visible proportions, without developing any new parts." In physiology, besides his studies of the nervous system, Haller studied the mechanism of respiration, refuting the teachings of Hamberger (1697-1755), who maintained that the lungs contract independently. Haller, however, in common with his contemporaries, failed utterly to understand the true function of the lungs. The great physiologist's influence upon practical medicine, while most profound, was largely indirect. He was a theoretical rather than a practical physician, yet he is credited with being the first physician to use the watch in counting the pulse. BATTISTA MORGAGNI AND MORBID ANATOMY A great contemporary of Haller was Giovanni Battista Morgagni (1682-1771), who pursued what Sydenham had neglected, the investigation in anatomy, thus supplying a necessary counterpart to the great Englishman's work. Morgagni's investigations were directed chiefly to the study of morbid anatomy--the study of the structure of diseased tissue, both during life and post mortem, in contrast to the normal anatomical structures. This work cannot be said to have originated with him; for as early as 1679 Bonnet had made similar, although less extensive, studies; and later many investigators, such as Lancisi and Haller, had made post-mortem studies. But Morgagni's De sedibus et causis morborum per anatomen indagatis was the largest, most accurate, and best-illustrated collection of cases that had ever been brought together, and marks an epoch in medical science. From the time of the publication of Morgagni's researches, morbid anatomy became a recognized branch of the medical science, and the effect of the impetus thus given it
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