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as demonstrated by Heinrich de Bary and by Max Schultze that the two are to all intents and purposes identical. Even earlier Remak had reached a similar conclusion, and applied Von Mohl's word protoplasm to animal cell contents, and now this application soon became universal. Thenceforth this protoplasm was to assume the utmost importance in the physiological world, being recognized as the universal "physical basis of life," vegetable and animal alike. This amounted to the logical extension and culmination of Schwann's doctrine as to the similarity of development of the two animate kingdoms. Yet at the same time it was in effect the banishment of the cell that Schwann had defined. The word cell was retained, it is true, but it no longer signified a minute cavity. It now implied, as Schultze defined it, "a small mass of protoplasm endowed with the attributes of life." This definition was destined presently to meet with yet another modification, as we shall see; but the conception of the protoplasmic mass as the essential ultimate structure, which might or might not surround itself with a protective covering, was a permanent addition to physiological knowledge. The earlier idea had, in effect, declared the shell the most important part of the egg; this developed view assigned to the yolk its true position. In one other important regard the theory of Schleiden and Schwann now became modified. This referred to the origin of the cell. Schwann had regarded cell growth as a kind of crystallization, beginning with the deposit of a nucleus about a granule in the intercellular substance--the cytoblastema, as Schleiden called it. But Von Mohl, as early as 1835, had called attention to the formation of new vegetable cells through the division of a pre-existing cell. Ehrenberg, another high authority of the time, contended that no such division occurs, and the matter was still in dispute when Schleiden came forward with his discovery of so-called free cell-formation within the parent cell, and this for a long time diverted attention from the process of division which Von Mohl had described. All manner of schemes of cell-formation were put forward during the ensuing years by a multitude of observers, and gained currency notwithstanding Von Mohl's reiterated contention that there are really but two ways in which the formation of new cells takes place--namely, "first, through division of older cells; secondly, through the formation of
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