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filament may be effected by the attacks of another organism. [Sidenote: Spores.] A very characteristic method of reproduction is that of spore-formation, and these minute reproductive bodies, which represent a resting stage of the organism, are now known in many forms. Formerly two kinds of spores were described, _arthrospores_ and _endospores_. An arthrospore, however, is not a true spore but merely an ordinary vegetative cell which separates and passes into a condition of rest, and such may occur in forms which form endospores, _e.g._ _B. subtilis_, as well as in species not known to form endospores. The true spore or endospore begins with the appearance of a minute granule in the protoplasm of a vegetative cell; this granule enlarges and in a few hours has taken to itself all the protoplasm, secreted a thin but very resistive envelope, and is a ripe ovoid spore, smaller than the mother-cell and lying loosely in it (cf. figs. 6, 9, 10, and 11). In the case of the simplest and most minute Schizomycetes [v.03 p.0162] (_Micrococcus_, &c.) no definite spores have been discovered; any one of the vegetative micrococci may commence a new series of cell by growth and division. We may call these forms "asporous," at any rate provisionally. [Illustration: FIG. 9. A. _Bacillus anthracis._ (After de Bary) Two of the long filaments (B, fig. 10) in which spores are being developed. The specimen was cultivated in broth, and spores are drawn a little too small--they should be of the same diameter transversely as the segments. B. _Bacillus subtilis._ (After de Bary.) 1, fragments of filaments with ripe spores; 2-5, successive stages in the germination of the spores, the remains of the spore attached to the germinal rodlets.] [Illustration: FIG. 10.--_Bacillus subtilis_. (After Strasburger.) A. Zoogloea pellicle. B. Motile rodlets. C. Development of spores.] The spore may be formed in short or long segments, the cell-wall of which may undergo change of form to accommodate itself to the contents. As a rule only one spore is formed in a cell, and the process usually takes place in a bacillar segment. In some cases the spore-forming protoplasm gives a blue reaction with iodine solutions. The spores may be developed in cells which are actively swarming, the movements not being interfered with by the process (fig. 4, D). The so-called "Koepfchenbacterien" of older writers are simply bacterioid segments with a spore at one end,
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