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established by the noise of this instrument. Ephemerides contains an account of a young man who became nervous and had the sense of suffocation when he heard the noise made by sweeping. Zimmerman speaks of a young girl who had convulsions when she heard the rustling of oiled silk. Boyle, the father of chemistry, could not conquer an aversion he had to the sound of water running through pipes. A gentleman of the Court of the Emperor Ferdinand suffered epistaxis when he heard a cat mew. La Mothe Le Vayer could not endure the sounds of musical instruments, although he experienced pleasurable sensations when he heard a clap of thunder. It is said that a chaplain in England always had a sensation of cold at the top of his head when he read the 53d chapter of Isaiah and certain verses of the Kings. There was an unhappy wight who could not hear his own name pronounced without being thrown into convulsions. Marguerite of Valois, sister of Francis I, could never utter the words "mort" or "petite verole," such a horrible aversion had she to death and small-pox. According to Campani, the Chevalier Alcantara could never say "lana," or words pertaining to woolen clothing. Hippocrates says that a certain Nicanor had the greatest horror of the sound of the flute at night, although it delighted him in the daytime. Rousseau reports a Gascon in whom incontinence of urine was produced by the sound of a bagpipe. Frisch, Managetta, and Rousse speak of a man in whom the same effect was produced by the sound of a hurdy-gurdy. Even Shakespeare alludes to the effects of the sound of bagpipes. Tissot mentions a case in which music caused epileptic convulsions, and Forestus mentions a beggar who had convulsions at the sound of a wooden trumpet similar to those used by children in play. Rousseau mentions music as causing convulsive laughter in a woman. Bayle mentions a woman who fainted at the sound of a bell. Paullini cites an instance of vomiting caused by music, and Marcellus Donatus mentions swooning from the same cause. Many people are unable to bear the noise caused by the grating of a pencil on a slate, the filing of a saw, the squeak of a wheel turning about an axle, the rubbing of pieces of paper together, and certain similar sounds. Some persons find the tones of music very disagreeable, and some animals, particularly dogs, are unable to endure it. In Albinus the younger the slightest perceptible tones were sufficient to produce an in
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