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ero's device combined mouth suction with a system of valves. Another famous inventor of assorted devices, Santorio Santorii (1561-1636), described a cup that contained a syringe in the early seventeenth century.[128] From the 1780s on, cups with brass syringes began to appear in compendia of instruments. A cup with brass fixings would be screwed onto a brass pump, placed on the skin, and the air within removed by a few strokes of the piston.[129] This sounded better in theory than it worked in practice. Expert cuppers agreed that they thoroughly disliked using the syringe. Mapleson (1813) offered three strong objections to the instrument. First, exhaustion could easily be carried too far, so as to obstruct the flow of blood. Second, the operation become tedious and fatiguing to the bloodletter because of the repeated screwing and unscrewing of syringe and glasses. Third, the valves were liable to malfunction.[130] Twenty-three years later Knox continued to disapprove of the syringe for the very same reasons. Of all the new inventions for cupping, he declared in 1836, "the worst is the syringe, as it makes that a most complicated and bungling operation that which, with common care and attention is one of the most simple in surgery."[131] Despite rejection by experienced cuppers, manufacturing of an air-tight syringe continued to challenge inventors throughout the nineteenth century. Some attempted to substitute stopcocks for valves, and some to place long flexible tubes between pump and glasses so that the pumping motions would not be communicated to the patient. Pumps were gradually improved, and, although rarely recommended by experts, were sold in great numbers as part of fancy and expensive cupping sets. These sets, with prices as high as fifteen dollars, consisted of a mahogany or leather box with brass latches, lined in plush, and containing compartments for scarificators, a brass pump, and an assortment of glasses provided with metal attachments. Some of the most elegant of the cupping sets were those made by Maison Charriere of Paris. Today the luxury of these cupping sets seems rather incongruous with the bloody purposes for which the instruments were used. Yet, the beauty of the instruments and their containers must have added to the esteem of the physician or surgeon in the mind of the patient. Syringes were not only useful in cupping but also were employed in a wide variety of medical and surgical operation
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