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and twitching of the limbs; white miliaria on the chest and abdomen; extreme debility, with settling towards the foot-end of the bed; changing pulse, which is at times slow, at others accelerated, feeble, intermittent: in such a case Apis requires more time to heal the mucous membrane of the alimentary canal; to restore the normal action of the bowels; to regulate the digestive functions; to procure quiet and refreshing sleep, and to gradually effect a complete restoration of health. If the mucous membrane of the respiratory organs was invaded by the morbid process, the cure was nevertheless completed as soon as the mucous lining of the intestinal canal was restored to its natural condition. So far, the only obstacle to a cure which I have witnessed, has been tuberculosis of the chest or abdominal viscera, or of both at the same time, and still more the vaccine-virus; likewise a tendency to paralysis in persons who were otherwise morbidly affected. Tuberculosis has often been combated by a single dose of a high potence of Sulphur between the doses of Apis, no Apis being given after the Sulphur, as long as the course of the typhoid symptoms would render it safe to postpone this medicine. I have found it much more difficult to conquer the vaccine-poison, _which I have become satisfied by years of observation, constitutes the most universal and most powerful generator of the typhus which is prevailing in our age and which seems unwilling to leave us_. Tartar emetic proves in this, as in other cases, its antidotal power against the vaccine-virus; but under no circumstances is more caution required in the use of tartar emetic than in typhus, where the vaccine-virus seeks to develop its characteristic pustules with a tendency inherent in each pustule to terminate in the destruction of the mucous membrane. It may seem hazardous to add to this combination of destructive forces another similarly-acting element; but a careful consideration of the circumstances of the case will justify such a proceeding, although death may be the inevitable result of the morbid process. Experience has satisfied me that the alternate use of tartar emetic and Apis, a drop of the third potency of each, every three, six or twelve hours, according as the symptoms are more or less violent, or, in very sensitive organisms, in tablespoonful doses of a watery solution of a drop, will accomplish all that can be expected; for these two drugs, thus administe
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