a grain of opium every four hours, and five grains of aloes
at night; and had a flannel shirt given him.

22.--Made sixteen pints. 23.--Thirteen pints: drinks less.

24.--Increased the opium to a grain and quarter every four hours: he made
twelve pints.

25.--Increased the opium to a grain and half: he now makes ten pints; and
drinks eight pints in a day.

The opium was gradually increased during the next fortnight, till he took
three grains every four hours, but without any further diminution of his
water. During the use of the opium he sweat much in the nights, so as to
have large drops stand on his face and all over him. The quantity of opium
was then gradually decreased, but not totally omitted, as he continued to
take about a grain morning and evening.

January 17.--He makes fourteen pints of water a day. Dr. Underhill now
directed him two scruples of common rosin triturated with as much sugar,
every six hours; and three grains of opium every night.

19.--Makes fifteen pints of water: sweats at night.

21.--Makes seventeen pints of water; has twitchings of his limbs in a
morning, and pains of his legs: he now takes a dram of rosin for a dose,
and continues the opium.

23.--Water more coloured, and reduced to sixteen pints, and he thinks has a
brackish taste.

26.--Water reduced to fourteen pints.

28.--Water thirteen pints: he continues the opium, and takes four scruples
of the rosin for a dose.

February 1.--Water twelve pints.

4.--Water eleven pints: twitchings less; takes five scruples for a dose.

8.--Water ten pints: has had many stools.

12.--Appetite less: purges very much.

After this the rosin either purged him, or would not stay on his stomach;
and he gradually relapsed nearly to his former condition, and in a few
months sunk under the disease.

October 3, Mr. Hughes evaporated two quarts of the water, and obtained from
it four ounces and half of a hard and brittle saccharine mass, like treacle
which had been some time boiled. Four ounces of blood, which he took from
his arm with design to examine it, had the common appearances, except that
the serum resembled cheese-whey; and that on the evidence of four persons,
two of whom did not know what it was they tasted, _the serum had a saltish
taste_.

From hence it appears, that the saccharine matter, with which the urine of
these patients so much abounds, does not enter the blood-vessels like the
nitre and asparagus mentioned above; but