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become concentrated into the desire for a little food, and immobility. If now, something is done to his sex apparatus, a marvelous transformation may be effected. That something no one could predict. It consists in slitting the genital duct, which leads from the germinal cells to the exterior. After the operation, the germinal cells, which grow into the spermatozoa, atrophy and disappear, since they can no longer function. As if released from some restraint, the interstitial cells, however, multiply enormously. With their multiplication, the miracle of rejuvenation is performed. After some weeks the sluggish currents of being in the rat, which had slowed down as a preliminary to stopping altogether, flow fast and furious. Waves of new chemical substances inundate his cells. And they respond like the fields that border the Nile after the annual flood. All his tissues, skin, muscle, nerve, even bone, are restored. A vitality is created which makes him bound and dart like a youth of his species. In due time, though, senility returns. It is as if a storage battery, recharged, runs down and becomes dead again. Slitting the genital duct of the other testis, causing its interstitial cells to hypertrophy and multiply, repeats the effects of the first experiment. The organism responds again to the new waves of vitality that vibrate through it. That it is recharged is demonstrated again by a revival of sex appetite and sex activity. The female which had become an object of indifference is reinstated as a creature to be sought and pursued. The second period ends in its turn. And now entirely new interstitial glands, in the form of fresh testes removed from a young animal, are transplanted into the body of the old rat. Once more youth returns. But now it burns itself more quickly than even before. An acute exhaustion of the mind appears first. Then all the other phenomena of old age steal back upon the old rat, and senility, firmly established in the saddle, rides him to the end. THE POSSIBILITIES OF REJUVENATION Whatever other deductions may be extracted from these experiments, they prove beyond a doubt the existence of an endocrine factor in the process of aging, as well as an arterial. They also demonstrate that the internal secretion of the sex glands, well advertised as it has been as the Elixir of Youth that Ponce de Leon, and Brown-Sequard with so many others, pursued in vain, is not the whole story. For if it was, th
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