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egnancy. Pregnant animals fed on thyroid give birth to young with large thymus glands. The diet of the mother has been proved conclusively to influence the development and constitution of the child. As the internal secretions influence the history of the food in the body, they affect development in the womb indirectly as well as directly. Certainly, whether or no we learn how to change the nature of germplasm within a short time, we have in the endocrines the means at hand for affecting _the whole individual that is born and sees the light of day_. THE CONTROL OF MUTATIONS The true physical and intellectual evolution of man depends upon the production of mutations of a desirable kind that can survive. The information furnished by the study of the endocrines concerning the genesis of personality provides the foundations for a positive eugenics, a eugenics of the encouragement of desirable matings, with the proper legal and social procedures. Selective breeding for the production of the best endocrine types should become practicable. But the biologist should be able to go farther. If the eugenist is to limit himself to the method of the animal breeder he will have to rest satisfied with the characters or hereditary factors given, that turn up spontaneously in an individual. But with the internal secretions as the controllable controllers of mutations, the outlook changes. It should become possible to produce new mutations, good and bad, to speed up their production at any rate. The feeding of thyroid to a gifted father before procreation might enhance immeasurably the chances of transmission of his gift as well as of its intensification in his offspring. A field of investigation is opened that would embrace in due time the deliberate control of human evolution. All the physical traits, stature, color, muscle function, and so on, offer themselves for improvement, as well as brain size, and the intellectual and emotional factors which have dominated man's social evolution. The general prevalence of nervous disorders in civilized countries, visible even in the nervous infants the specialist in children's diseases is called upon to treat, shows that the nervous system of the better part of mankind is in a state of unstable equilibrium. It may be another example of the curious coincidences that have been called the Fitness of the Environment that the investigation of the endocrines promises to put into our hands the
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