female, while abnormal metabolism is dominant in the female and
recessive in the male. If an endocrine abnormality like a goitre,
or cretinism, or a dwarf or giant appear in a family as a sign of
endocrine instability, other members of that family will very likely
show internal secretion abnormalities.

If one gland of internal secretion acts as the centre of the system
and the others as satellites, we should be able to trace what happens
to it in the different generations. Does it maintain its supremacy? Or
will it be ousted by another member of the group? The time will come
when we shall thus be able to advise prospective parents of the
consequences of procreation and to forecast the meaning for the race
of a particular marriage. Internal glandular analysis may become
legally compulsory for those about to mate before the end of the
present century.

What are desirable and undesirable matings? The general law followed
by nature in her helterskelter way seems to be the production of the
greatest number of hybrids and variations possible, whether for
good or evil does not matter. Certain endocrine types appear to be
specially attracted to others belonging to the same group. Thus
thymus-centered types frequently marry. The ante-pituitary type of
male, the strongly masculine, mates often with the post-pituitary type
of female, the markedly feminine. The children exhibit the lineaments
of the pituitary-centered type. The general trend seems to be the
establishment of a better balanced, equilibrated type. Yet the
children often are apt to segregate into pituitary dominants or
pituitary deficients. Happiness and unhappiness in marriage should
be examined from the standpoint of endocrine compatibility or
incompatibility. Likewise those divorced or about to be divorced.

The correction of endocrine defects, disturbances, imbalances and
instabilities, before mating, presents another field. It remains to be
seen whether we shall thereby, in one generation, be able to affect
at all the germplasm, hitherto revered by all pious biologists as an
environment-proof holy of holies. No one can deny, in the face of the
multitude of evidence available, that internal secretion disturbances
occur in the mother, which, when grave, offer in the infant gross
proof of their significance, and therefore when slight must more
subtly work upon it. Endocrine disturbances in infancy have been
traced to endocrine disturbances in the mother during pr