assium iodide, after which four more weekly
injections of 0.6 grm. of "914" are given.

With each injection of "914" after the first, throughout the whole
course 1 grain of mercury is injected intra-muscularly.

In the course of a few hours, there is usually some indisposition, with
a feeling of chilliness and slight rise of temperature; these symptoms
pass off within twenty-four hours, and in a few days there is a decided
improvement of health. Three or four days after an intra-muscular
injection there may be pain and stiffness in the gluteal region.

These preparations are the most efficient therapeutic agents that have
yet been employed in the treatment of syphilis.

The manifestations of the disease disappear with remarkable rapidity.
Observations show that the spirochaetes lose their capacity for movement
within an hour or two of the administration, and usually disappear
altogether in from twenty-four to thirty-six hours. Wassermann's
reaction usually yields a negative result in from three weeks to two
months, but later may again become positive. Subsequent doses of the
arsenical preparation are therefore usually indicated, and should be
given in from 7 to 21 days according to the dose.

When syphilis occurs in a _pregnant woman_, she should be given in the
early months an ordinary course of "914," followed by 10-grain doses of
potassium iodide twice daily. The injections may be repeated two months
later, and during the remainder of the pregnancy 2-grain mercury pills
are given twice daily (A. Campbell). The presence of albumen in the
urine contra-indicates arsenical treatment.

It need scarcely be pointed out that the use of powerful drugs like
"606" and "914" is not free from risk; it may be mentioned that each
dose contains nearly three grains of arsenic. Before the administration
the patient must be overhauled; its administration is contra-indicated
in the presence of disease of the heart and blood vessels, especially a
combination of syphilitic aortitis and sclerosis of the coronary
arteries, with degeneration of the heart muscle; in affections of the
central nervous system, especially advanced paralysis, and in such
disturbances of metabolism as are associated with diabetes and Bright's
disease. Its use is not contra-indicated in any lesion of active
syphilis.

The administration is controlled by the systematic examination of the
urine for arsenic.

_The Administration of Mercury._--The success of th