agents, was expelled from the realm of college authority;
ether was substituted for nitrous oxide, and chloroform preferred to
ether, until frequent deaths gave warning.

Nitrous oxide, much the safest of the three, has not been the
favorite, but has held its ground, especially with dentists. But even
nitrous oxide is not perfect. It is not equal to the magnetic sleep,
when the latter is practicable, but fortunately it is applicable to
all. To perfect the nitrous oxide, making it universally safe and
pleasant, Dr. U. K. Mayo, of Boston, has combined it with certain
harmless vegetable nervines, which appear to control the fatal
tendency which belongs to all anaesthetics when carried too far. The
success of Dr. Mayo, in perfecting our best anaesthetic, is amply
attested by those who have used it. Dr. Thorndike, than whom, Boston
had no better surgeon, pronounced it "the safest the world has yet
seen." It has been administered to children and to patients in extreme
debility. Drs. Frizzell and Williams, say they have given it
"repeatedly in heart disease, severe lung diseases, Bright's disease,
etc., where the patients were so feeble as to require assistance in
walking, many of them under medical treatment, and the results have
been all that we could ask--no irritation, suffocation, nor
depression. We heartily commend it to all as the anaesthetic of the
age." Dr. Morrill, of Boston, administered Mayo's anaesthetic to his
wife with delightful results when "her lungs were so badly
disorganized, that the administration of ether or gas would be
entirely unsafe." The reputation of this anaesthetic is now well
established; in fact, it is not only safe and harmless, but has great
medical virtue for daily use in many diseases, and is coming into use
for such purposes. In a paper before the Georgia State Dental Society,
Dr. E. Parsons testified strongly to its superiority. "The nitrous
oxide, (says Dr. P.) causes the patient when fully under its influence
to have very like the appearance of a corpse," but under this new
anaesthetic "the patient appears like one in a natural sleep." The
language of the press, generally has been highly commendatory, and if
Dr. Mayo had occupied so conspicuous a rank as Prof. Simpson, of
Edinburgh, his new anaesthetic would have been adopted at once in every
college of America and Europe.

* * * * *

Mayo's Vegetable Anaesthetic.

A perfectly sa