1-1/2 "
Aqua destil 1-1/2 drams.

As a diagnostic this mixture of the two is said to be far superior to
either cocaine or morphia alone.

In connection with this subject, Professor Hobday has published, among
others, the following cases illustrating the practical value of this method
of diagnosis:[A]

[Footnote A: The _Journal of Comparative Pathology and Therapeutics_ vol.
viii., pp. 27, 43.]

CASE I.--Cab gelding. Seat of lameness somewhat obscure; navicular disease
suspected. Injected 2 grains of cocaine in aqueous solution on either side
of the limb, immediately over the metacarpal nerves.

_Five Minutes_.--Lameness perceptibly diminished.

_Ten Minutes_.--Lameness scarcely perceptible.

CASE II.--Mare. Obscure lameness; foot suspected. Injected 30 minims of a 5
per cent. solution on either side of the leg just above the fetlock.

_Ten Minutes_.--No lameness, thus proving that the seat of lameness was
below the point of injection.

CASE III.--Cab gelding, aged, free clinique; Messrs. Elme's and Moffat's
case. Obscure lameness; foot suspected of navicular disease; very lame.
Injected 30 minims of a 5 per cent. solution of cocaine on either side of
the leg over the metacarpal nerves.

_Six Minutes_.--Lameness perceptibly less; there was no response whatever
on the inside of the leg to the prick of a pin. On the outside, which had
not been injected so thoroughly, there was sensation, although not so much
as in a healthy foot.

_Ten Minutes_.--Lameness had almost disappeared; so much so, that the
opinion as to navicular disease was confirmed, and neurectomy was
performed. Immediately after this operation there was no lameness whatever.

The same author also reports numerous cases among horses and cattle, dogs
and cats, pointing out the toxic properties of the drug. The symptoms
following an overdose are interesting enough to relate here, and I select
the following case of Professor Hobday's as being fairly typical:[A]

[Footnote A: _Loc. cit_.]

CASE IV.--Cart gelding. Free clinique; navicular disease. Injected
subcutaneously over the metacarpal nerves on each side 6 grains of cocaine
in aqueous solution. During the operation the animal manifested no signs
of pain whatever, not even when the nerve was cut. This animal received
altogether 12 grains of cocaine (3 grains were given on either side first,
then fifteen minutes afterwards the same dose repeated). The effect