e patient had a peculiar bowed
condition of the legs, with marked flexure at the knees. He finally
died of osteosarcoma, originating in the left radius, Paget collected
eight cases, five of whom died of malignant disease. The postmortem of
Paget's case showed extreme thickening in the bones affected, the femur
and cranium particularly showing osteoclerosis. Several cases have been
recorded in this country; according to Warren, Thieberge analyzed 43
cases; 21 were men, 22 women; the disease appeared usually after forty.

Acromegaly is distinguished from osteitis deformans in that it is
limited to hypertrophy of the hands, feet, and face, and it usually
begins earlier. In gigantism the so-called "giant growth of bones" is
often congenital in character, and is unaccompanied by inflammatory
symptoms.

The deformities of the articulations may be congenital but in most
cases are acquired. When these are of extreme degree, locomotion is
effected in most curious ways. Ankylosis at unnatural angles and even
complete reversion of the joints has been noticed. Pare gives a case of
reversion, and of crooked hands and feet; and Barlow speaks of a child
of two and three-quarter years with kyphosis, but mobility of the
lumbar region, which walked on its elbows and knees. The pathology of
this deformity is obscure, but there might have been malposition in
utero. Wilson presented a similar case before the Clinical Society of
London, in 1888. The "Camel-boy," exhibited some years ago throughout
the United States, had reversion of the joints, which resembled those
of quadrupeds. He walked on all fours, the mode of progression
resembling that of a camel.

Figure 216 represents Orloff, "the transparent man," an exhibitionist,
showing curious deformity of the long bones and atrophy of the
extremities. He derived his name from the remarkable transparency of
his deformed members to electric light, due to porosity of the bones
and deficiency of the overlying tissues.

Figure 217, taken from Hutchinson's "Archives of Surgery," represents
an extreme case of deformity of the knee-joints in a boy of seven, the
result of severe osteoarthritis. The knees and elbows were completely
ankylosed.

Infantile spinal paralysis is often the cause of distressing
deformities, forbidding locomotion in the ordinary manner. In a paper
on the surgical and mechanical treatment of such deformities Willard
mentions a boy of fourteen, the victim of infantile paral