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n his Treatise on Human Physiology.[H] "This operation is difficult," writes Professor Flint, "but we have several times performed it with entire success;" and his assistant at Bellevue Medical College has succeeded "in extirpating these nerves for class demonstrations."[I] In withdrawal of blood from the hepatic veins of a dog, "avoiding the administration of an anaesthetic" is one of the steps recommended.[J] The curious experiment of Bernard, in which artificial diabetes is produced by irritating the floor of the fourth ventricle of the brain, is carefully described, and illustrations afforded both of the instrument and the animal undergoing the operation. The inexperienced experimenter is here taught to hold the head of the rabbit "firmly in the left hand," and to bore through its skull "by a few lateral movements of the instrument." It is not a difficult operation; it is one which the author has "often repeated." He tell us "_it is not desirable to administer an anaesthetic_," as it would prevent success; and a little further we are told that "we should avoid the administration of anaesthetics in all accurate experiments on the glycogenic function."[K] It is true the pleasing assurance is given that "this experiment is almost painless"; but on this point, could the rabbit speak during the operation, its opinion might not accord with that of the physiologist. [A] A Text-book of Human Physiology, designed for the use of Practitioners and Students of Medicine, by Austin Flint, Jr., M. D. D. Appleton & Co. New York: 1876 (page 722). [B] Page 738. [C] Page 585. [D] Page 710. [E] Page 403. [F] Pages 269-70. [G] Page 282. [H] Page 489. [I] Page 629. [J] Page 463. [K] Pages 470-71. There is one experiment in regard to which the severe characterization of English scientists is especially applicable, from the pain necessarily attending it. Numerous investigators have long established the fact that the great sensory nerve of the head and face is endowed with an exquisite degree of sensibility. More than half a century ago, both Magendie and Sir Charles Bell pointed out that merely exposing and touching this fifth nerve gave signs of most acute pain. "All who have divided this root in living animals must have recognized, not only that it is sensitive, but that its sensibility is far more acute than that of any other nervous trunk in the body."[A
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