xually, may suffer from a definite insomnia,
is emotional, and perspires freely. Alert, neurotic or high-strung,
magnetic, and imaginative are some of the descriptive adjectives
applicable. The eyes are bright and prominent, large and beautiful,
when they have not reached the stage entitled "pop-eyed." Or they may
even become so protuberant and bulging as to develop the expression of
one staring aghast at some ineffable horror. The latter is the feature
of only the severest types, when there is an associated goitre, the
combination designated as exopthalmic goitre.

There are, too, individuals in whom hyperthyroidism and hypothyroidism
are mixed, or rather alternate. At one time they present the phenomena
of the one, at another of the other. They are the people who complain
of the cyclic quality of their moods and purposes. Their mood will
be a heaven of exaltation and exhilaration, and then descend into a
slough of despond from which they feel themselves inextricable. They
are always talking about the ups and downs of their mental states.
Headache and languor and fatigability, dry skin and lack of appetite
for food or exertion on one day or for one week, give way on the next
day, or for the next week, to an energetic gayety, and sweaty, flushed
skin, a prominent appetite for food and every sort of activity. Driven
to be forever on the go, for one period, in the next they feel like
lying down most of the day, with no inclination for any life whatever.
The stage of depression may go as far as a melancholia, the stage of
stimulation as far as mania. They may simulate manic-depressive or
cyclic insanity. Something restrains them, and holds them bound as in
a vise in the one cycle. And then they are driven on beyond themselves
by some invisible whip in the next.

THYROID AS DIFFERENTIATOR

Besides the action of the thyroid as energizer, lubricator, and growth
catalyzer, it has a remarkable power as a differentiator of tissues.
It determines the embryonic etchings of the different organs which in
their totality comprise the unique individual. Every multicellular
animal must first have existed as a single cell, the impregnated ovum.
With the body and personality of the ovum, the creature is one and
continuous, literally something the single cell has made of itself by
sub-dividing and differentiating. In the process, the cell mass often
goes through stages which stand out as individualities in themselves,
that appear on the