the local lesion with
a mild antiseptic dressing, and relying upon general treatment.

The general treatment consists in feeding and stimulating the patient as
freely as possible. Quinine, in 5 to 10 grain doses every four hours,
and powdered ipecacuanha, in 40 to 60 grain doses every four hours, have
also been employed with apparent benefit.

GLANDERS

Glanders is due to the action of a specific bacterium, the _bacillus
mallei_, which resembles the tubercle bacillus, save that it is somewhat
shorter and broader, and does not stain by Gram's method. It requires
higher temperatures for its cultivation than the tubercle bacillus, and
its growth on potato is of a characteristic chocolate-brown colour, with
a greenish-yellow ring at the margin of the growth. The bacillus mallei
retains its vitality for long periods under ordinary conditions, but is
readily killed by heat and chemical agents. It does not form spores.

_Clinical Features._--Both in the lower animals and in man the bacillus
gives rise to two distinct types of disease--_acute glanders_, and
_chronic glanders_ or _farcy_.

Acute Glanders is most commonly met with in the horse and in other
equine animals, horned cattle being immune. It affects the septum of the
nose and adjacent parts, firm, translucent, greyish nodules containing
lymphoid and epithelioid cells appearing in the mucous membrane. These
nodules subsequently break down in the centre, forming irregular
ulcers, which are attended with profuse discharge, and marked
inflammatory swelling. The cervical lymph glands, as well as the lungs,
spleen, and liver, may be the seat of secondary nodules.

_In man_, acute glanders is commoner than the chronic variety. Infection
always takes place through an abraded surface, and usually on one of the
uncovered parts of the body--most commonly the skin of the hands, arms,
or face; or on the mucous membrane of the mouth, nose, or eye. The
disease has been acquired by accidental inoculation in the course of
experimental investigations in the laboratory, and proved fatal. The
incubation period is from three to five days.

The _local_ manifestations are pain and swelling in the region of the
infected wound, with inflammatory redness around it and along the lines
of the superficial lymphatics. In the course of a week, small, firm
nodules appear, and are rapidly transformed into pustules. These may
occur on the face and in the vicinity of joints, and may be mistaken