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an kill." --Dryden. So distressing a malady as epilepsy early attracted attention, and every treatment superstition could devise, or science could suggest, has been tried. Culpepper in his "Herbal" (300 years old), recommends bryony; lunar caustic (nitrate of silver) was extensively used, because silver was the colour of the moon, which caused madness. The royal touch for scrofula (King's Evil) was also extended to epilepsy, the king blessing a ring, which was worn by the sufferer. Another old remedy was to cut off a lock of the victim's hair while in a seizure and put it in his hand, which stopped (?) the attack. In Berkshire a piece of silver collected at the communion service and made into a ring was specific, but in Devon a ring made of three nails from an old coffin was preferred. Lupton says: "A piece of child's navel-string borne in a ring is good against falling sickness." Nearly every drug in the Pharmacopoeia has been tried, the drugs now generally used being sodium, potassium and ammonium bromide. Before bromides were introduced by Locock in 1857, very strict hygienic, dietic and personal disciplinary treatment combined with the use of drugs often effected improvement. Since the use of bromides, these personal habits have, unfortunately, been neglected, far too much reliance being placed on the "three times a day after meals" formula. All bromides are quickly absorbed from the stomach and bowels, and enter the blood as sodium bromide, which lowers the activity of both motor and sensory centres, and renders the brain less sensitive to disturbing influences. Unfortunately, the influence of bromides is variable, uncertain, and markedly good in only a small proportion of cases. In about 25 per cent of cases, in which mild seizures occur at long periods, without mental impairment, the bromides arrest the seizures, either temporarily or permanently, after a short course. In another 25 per cent the bromides lessen the frequency and severity of the fits, this being the common _temporary_ result of their use in _all cases_ in the first stages. In quite 50 per cent of cases, the effect of bromides diminishes as they are continued, and they finally exert no influence at all. Many cases are temporarily "cured", the drug is stopped, and the seizures recur. Bromides are valuable in recent and mild cases, but no medicine exerts much effect on severe cases of long standing, which usually
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