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ct, and particularly where the literature was controversial, my results have been completely haywire. Needless to say, I was not happy with this so I discussed it with other graduate students. They have all encountered the _same thing_! But most professors won't admit this to be true and merely tell me that my technique is lousy. If anything, I am an overly careful worker. Why is it when I _know_ what results are expected, I get comparable results even on the _first_ trial? Remember, _I obtained the expected results_ when the literature wasn't confused or when my sponsor--a most important man in my life--gave me a clue as to what kind of results to expect. _Only then._ Now this is the heart of the matter.... The obvious explanation is the lack of experience. But, and this is what haunts me ... _what if those so-called contradictory results are meaningful_? What if they were executed with care--_and they were_--and are not the results of sloppiness or inexperience? _What if a nerve can twitch?_ Very respectfully yours, Jonathan Wells * * * * * May 3, 1958 Dr. Robert Von Engen, Editor, Journal of the National Academy of Sciences, Constitution Avenue, Washington, D. C. Dear Dr. Von Engen: I would like to thank you for your encouraging letter and advice. I agree completely with your statement that science has a long way to go before we can explain the various inconsistencies that crop up in research. But I certainly can't see how the letter is far too "unsophisticated" for inclusion in the _Letters to the Editor_ portion of your journal. While your letter should have calmed me, I feel even more strongly now after a year of research about the matter than I did before. I have deliberately postponed answering your letter until I had more _facts_. I now find that I have accumulated--as you suggested--three distinctly conflicting groups of data on nucleic acid synthesis of frog liver cells: 1. There is a conversion of ribonucleic acid to desoxyribonucleic acid. 2. There is a conversion of desoxyribonucleic acid to ribonucleic acid. 3. The synthesis of both types of nucleic acid are independent of each other. (In addition, I have some data ... that I don't want to think about too much ... that shows that there is absolutely no nucleic acid in the liver cell.) Thus, these data all accumulated by experimental work, support all three hypotheses. Moreover, the literatur
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