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tance._ It is well known that there are present in the body certain agencies which act as guardians of the body against disease; that there are certain corpuscles of the blood and certain liquids circulating through the system which immediately attack and if in sufficient numbers or strength drive out the advancing enemy, so that "taking a disease" in most cases means that the activity of these resisting organisms is not forceful enough to successfully combat the germs of the disease. These agencies, whether circulating liquids or cells or corpuscles, are most active in the healthy body, and anything that tends to reduce the general health, such as exposure, overexertion, imperfect nourishment, overeating or overdrinking, or lack of sleep, tends to diminish their activity and so makes the individual more susceptible to disease. _Cell disintegration._ Although disease is caused by the attacks of germs, another and far more important cause of disease is the breaking down or overstimulation of some particular organ. This is very plainly seen in diseases involving the stomach or intestines, where habitual excesses in eating lead, sooner or later, to consequent inflammation, disease, and death. This is also true of the lungs; merely living in an atmosphere full of dust will irritate the lungs to such a degree as to cause inflammation. Cancer is presumably the result of local inflammation, although the cause of the original suppuration is unknown. Similarly, appendicitis starts from some irritating cause, resulting in inflammation and the formation of pus. In very many cases the cell-disintegration seems to be a matter of heredity. _Heredity._ Heredity, the second of the indirect causes of disease seems to be assuming less importance as it is more studied. Probably in but few cases is heredity more than a chance factor in the causation of disease. Heredity, formerly considered to be the most important cause of consumption, is now understood to have little to do with this widespread epidemic, although it is agreed that children brought up in the family with a consumptive mother and father are more likely to contract the disease than if they were segregated. It is a providential arrangement that children inherit the tendencies of both father and mother, and that the good qualities of one parent are known to offset the bad qualities of the other; probably for this very important physiological reason marriage between
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