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give us indications of these conditions. A complete cycle of molecular modifications can be traced, from the abnormal negative to the normal positive, and then again to negative seen in reversal under continuous stimulation. FOOTNOTES: [16] 'Considering that we have no previous evidence of any chemical or physical change in tetanised nerve, it seems to me not worth while pausing to deal with the criticism that it is not CO_2, but "something else" that has given the result.'--Waller, _Animal Electricity_, p. 59. That this phenomenon is nevertheless capable of physical explanation will be shown presently. [17] In order to explain the phenomena of electric response, some physiologists assume that the negative response is due to a process of dissimilation, or breakdown, and the positive to a process of assimilation, or building up, of the tissue. The modified or positive response in nerve is thus held to be due to assimilation; after continuous stimulation, this process is supposed to be transformed into one of dissimilation, with the attendant negative response. How arbitrary and unnecessary such assumptions are will become evident, when the abnormal and normal responses, and their transformation from one to the other, are found repeated in all details in metals, where there can be no question of the processes of assimilation or dissimilation. CHAPTER XV INORGANIC RESPONSE--RELATION BETWEEN STIMULUS AND RESPONSE--SUPERPOSITION OF STIMULI Relation between stimulus and response--Magnetic analogue--Increase of response with increasing Stimulus--Threshold of response--Superposition of Stimuli--Hysteresis. #Relation between stimulus and response.#--We have seen what extremely uniform responses are given by tin, when the intensity of stimulus is maintained constant. Hence it is obvious that these phenomena are not accidental, but governed by definite laws. This fact becomes still more evident when we discover how invariably response is increased by increasing the intensity of stimulus. Electrical response is due, as we have seen, to a molecular disturbance, the stimulus causing a distortion from a position of equilibrium. In dealing with the subject of the relation between the disturbing force and the molecular effect it produces, it may be instructive to consider certain analogous physical phenomena in which molecular deflections are also produced by a distorting force. #Magnetic analogue
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