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ferent species of the same class, according to the special organization of the animal and the general activity of its functions. The temperature of the frog may be 85 degrees F. in June and 41 degrees F. in January. The structure of its tissues is unaltered and their vitality unimpaired by such violent fluctuations. But in man it is necessary not only for health, but even for life, that the temperature should vary only within narrow limits around the mean of 98-1/2 degrees F. We are ignorant of the precise significance of this constancy of temperature in warm-blooded animals, which is as important and peculiar as their average height, Man, undoubtedly, must possess a superior delicacy of organization, hardly revealed by structure, which makes it necessary that he should be shielded from the shocks and jars of varying temperature, that less highly endowed organisms endure with impunity. 224. Sources of Bodily Heat. The heat of the body is generated by the chemical changes, generally spoken of as those of oxidation, which are constantly going on in the tissues. Indeed, whenever protoplasmic materials are being oxidized (the process referred to in sec. 15 as katabolism) heat is being set free. These chemical changes are of various kinds, but the great source of heat is the katabolic process, known as oxidation. The vital part of the tissues, built up from the complex classes of food, is oxidized by means of the oxygen carried by the arterial blood, and broken down into simpler bodies which at last result in urea, carbon dioxid, and water. Wherever there is life, this process of oxidation is going on, but more energetically in some tissues and organs than in others. In other words, the minutest tissue in the body is a source of heat in proportion to the activity of its chemical changes. The more active the changes, the greater is the heat produced, and the greater the amount of urea, carbon dioxid, and water eliminated. The waste caused by this oxidation must be made good by a due supply of food to be built up into protoplasmic material. For the production of heat, therefore, food is necessary. But the oxidation process is not as simple and direct as the statement of it might seem to indicate. Though complicated in its various stages, the ultimate result is as simple as in ordinary combustion outside of the body, and the products are the same. The continual chemical changes, then, chiefly by oxidation of combustible
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